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Tadalafil (trade name "Cialis" or "Adcirca") is a PDE5 inhibitor used to treat erectile dysfunction, benign prostatic hypertrophy, and pulmonary hypertension. Tadalafil works by relaxing the vascular muscles and increasing blood flow to the cavernous body. Tadalafil acts by inhibiting the activity of CGMP-specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the cavernous body that surrounds the penis. Therefore, tadalafil causes an increase in cGMP concentration, which further causes smooth muscle relaxation and increased blood flow to the cavernous body. Some clinical studies have also shown that tadalafil can improve endothelial function in men at increased cardiovascular risk and reduce urinary tract symptoms secondary to benign prostatic hyperplasia.

use

Analgesics, norepinephrine uptake blockers, μ-opioid receptor agonists. Phosphodiesterase 5 inhibitors. Tadalafil is used to treat erectile dysfunction. Tadalafil is used to treat erectile dysfunction. Phosphodiesterase 5 inhibitors.